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The pharmaceutical dosage form of claim 11, wherein the outer ph-sensitive polymer layer dissolves at a ph of about 5 or higher.

1. Indicated that for -hemolytic streptococcus spp, the most efficacious antimicrobial agents were erythromycin, cephalothin, chloramphenicol, and carbenicillin.
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3. Antimicrobial agents tested were azythromycin azt;, clindamycin cdm;, erythromycin etm;, enrofloxacin enr;, spectinomycin stm; and tetracycline te;.
4. However, the outcomes in children from populations where there is an ibcreased risk of complications remain uncertain.

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